GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs951366 | 1 | rs4951261 | chr1:205717823 | PM20D1 | chr1:205797154-205819245:- | 0.34 | 5.95 | 5.21E-9 | Menarche (age at onset) |
| THCA | cis | rs951366 | 1 | rs4951261 | chr1:205717823 | RAB7L1 | chr1:205737115-205744610:- | -0.3 | -8.63 | 8.93E-17 | Menarche (age at onset) |
| THCA | cis | rs4952590 | 1 | rs4952589 | chr2:42276606 | COX7A2L | chr2:42577647-42596150:- | 0.19 | 3.35 | 0.000866 | Atopy |
| THCA | cis | rs494562 | 1 | rs495469 | chr6:86117025 | NT5E | chr6:86159302-86205496:+ | 0.24 | 3.76 | 0.000191 | Blood metabolite levels;Metabolic traits |
| THCA | cis | rs494562 | 1 | rs495472 | chr6:86117021 | NT5E | chr6:86159302-86205496:+ | 0.24 | 3.76 | 0.000191 | Blood metabolite levels;Metabolic traits |
| THCA | cis | rs10935120 | 1 | rs4955485 | chr3:134295843 | ANAPC13 | chr3:134196547-134204865:- | 0.36 | 11.4 | 8.25E-27 | Height |
| THCA | cis | rs10935120 | 1 | rs4955485 | chr3:134295843 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.62 | 9.81E-11 | Height |
| THCA | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.9 | 7.22E-33 | Height |
| THCA | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.55 | 1.51E-10 | Height |
| THCA | cis | rs7116495 | 1 | rs495567 | chr11:71795488 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.97 | 8.36E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs17132261 | 1 | rs4957901 | chr5:109707457 | TMEM232 | chr5:109624934-110062381:- | 0.38 | 4.51 | 8.32E-6 | Cardiac structure and function |
| THCA | cis | rs7714584 | 1 | rs4958422 | chr5:150186734 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.77 | 1.39E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958422 | chr5:150186734 | ZNF300 | chr5:150273964-150284391:- | 0.18 | 3.63 | 0.00032 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958424 | chr5:150225036 | LOC134466 | chr5:150310000-150326146:- | 0.39 | 5.45 | 8.07E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958426 | chr5:150278346 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.05 | 2.88E-9 | Crohn's disease |